Identification of MHC-I-Presented Porcine Respiratory and Reproductive Syndrome Virus (PRRSV) Peptides Reveals Immunogenic Epitopes within Several Non-Structural Proteins Recognized by CD8<sup>+</sup> T Cells.

Mötz, Marlene; Stas, Melissa R; Hammer, Sabine E; Duckova, Tereza; Fontaine, Frederic; Kiesler, Alexandra; Seitz, Kerstin; Ladinig, Andrea; Müller, André C; Riedel, Christiane; Saalmüller, Armin; Rümenapf, Till

Identification of MHC-I-Presented Porcine Respiratory and Reproductive Syndrome Virus (PRRSV) Peptides Reveals Immunogenic Epitopes within Several Non-Structural Proteins Recognized by CD8⁺ T Cells.

Mötz, Marlene; Stas, Melissa R; Hammer, Sabine E; Duckova, Tereza; Fontaine, Frederic; Kiesler, Alexandra; Seitz, Kerstin; Ladinig, Andrea; Müller, André C; Riedel, Christiane; Saalmüller, Armin; Rümenapf, Till.

Afiliação

Mötz M; Institute of Virology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
Stas MR; Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
Hammer SE; Institute of Immunology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
Duckova T; Institute of Immunology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
Fontaine F; CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria.
Kiesler A; Institute of Virology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
Seitz K; Institute of Virology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
Ladinig A; Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
Müller AC; CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria.
Riedel C; Institute of Virology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
Saalmüller A; Institute of Immunology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
Rümenapf T; Institute of Virology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria.

Viruses ; 14(9)2022 08 26.

Article em En | MEDLINE | ID: mdl-36146698

Assuntos

Síndrome Respiratória e Reprodutiva Suína; Vírus da Síndrome Respiratória e Reprodutiva Suína; Vacinas Virais; Animais; Anticorpos Neutralizantes; Anticorpos Antivirais; Linfócitos T CD8-Positivos; Cromatografia Líquida; Citocinas; Epitopos; Leucócitos Mononucleares; Complexo Principal de Histocompatibilidade; Peptídeos; Suínos; Espectrometria de Massas em Tandem; Vacinas Atenuadas; Vacinas de Produtos Inativados

Palavras-chave

Arteriviridae; CD8+ T cells; PRRSV; epitopes; immunopeptidomics; intracellular cytokine staining; major histocompatibility complex class I; mass spectrometry; porcine reproductive and respiratory syndrome virus; restimulation; swine leukocyte antigen class I

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas Virais / Vírus da Síndrome Respiratória e Reprodutiva Suína / Síndrome Respiratória e Reprodutiva Suína Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Viruses Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Áustria

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