Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss.

Clark, Andrew; Ghatak, Subhadip; Guda, Poornachander Reddy; El Masry, Mohamed S; Xuan, Yi; Sato, Amy Y; Bellido, Teresita; Sen, Chandan K

Clark, Andrew; Ghatak, Subhadip; Guda, Poornachander Reddy; El Masry, Mohamed S; Xuan, Yi; Sato, Amy Y; Bellido, Teresita; Sen, Chandan K.

Afiliação

Clark A; Indiana Center for Regenerative Medicine and Engineering, Indiana University Health Comprehensive Wound Center, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Ghatak S; Indiana Center for Regenerative Medicine and Engineering, Indiana University Health Comprehensive Wound Center, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Guda PR; Indiana Center for Regenerative Medicine and Engineering, Indiana University Health Comprehensive Wound Center, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
El Masry MS; Indiana Center for Regenerative Medicine and Engineering, Indiana University Health Comprehensive Wound Center, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Xuan Y; Indiana Center for Regenerative Medicine and Engineering, Indiana University Health Comprehensive Wound Center, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Sato AY; Birck Nanotechnology Center and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
Bellido T; Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Sen CK; Central Arkansas Veterans Healthcare System, Little Rock, AR, 72205, USA.

NPJ Regen Med ; 7(1): 63, 2022 Oct 20.

Article em En | MEDLINE | ID: mdl-36266362

ABSTRACT

ABSTRACT

This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNTMyoD) to injured tissue in vivo. TNTMyoD was performed on skin and successfully induced expression of myogenic factors. TNTMyoD was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNTMyoD is promising as VML intervention.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: NPJ Regen Med Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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