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Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease.
Dehghan, Abbas; Pinto, Rui Climaco; Karaman, Ibrahim; Huang, Jian; Durainayagam, Brenan R; Ghanbari, Mohsen; Nazeer, Areesha; Zhong, Qi; Liggi, Sonia; Whiley, Luke; Mustafa, Rima; Kivipelto, Miia; Solomon, Alina; Ngandu, Tiia; Kanekiyo, Takahisa; Aikawa, Tomonori; Radulescu, Carola I; Barnes, Samuel J; Graça, Gonçalo; Chekmeneva, Elena; Camuzeaux, Stephane; Lewis, Matthew R; Kaluarachchi, Manuja R; Ikram, M Arfan; Holmes, Elaine; Tzoulaki, Ioanna; Matthews, Paul M; Griffin, Julian L; Elliott, Paul.
Afiliação
  • Dehghan A; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London SW7 2AZ, United Kingdom.
  • Pinto RC; Medical Research Council Centre for Environment and Health, School of Public Health, Imperial College London, Norfolk Place, London SW7 2AZ, United Kingdom.
  • Karaman I; UK Dementia Research Institute at Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom.
  • Huang J; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London SW7 2AZ, United Kingdom.
  • Durainayagam BR; UK Dementia Research Institute at Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom.
  • Ghanbari M; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London SW7 2AZ, United Kingdom.
  • Nazeer A; UK Dementia Research Institute at Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom.
  • Zhong Q; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London SW7 2AZ, United Kingdom.
  • Liggi S; UK Dementia Research Institute at Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom.
  • Whiley L; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, 138632 Singapore.
  • Mustafa R; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London SW7 2AZ, United Kingdom.
  • Kivipelto M; UK Dementia Research Institute at Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom.
  • Solomon A; Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, United Kingdom.
  • Ngandu T; Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000, the Netherlands.
  • Kanekiyo T; Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, United Kingdom.
  • Aikawa T; The Rowett Institute, University of AberdeenForesterhill Campus, Aberdeen AB24 3FX, United Kingdom.
  • Radulescu CI; UK Dementia Research Institute at Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom.
  • Barnes SJ; Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, United Kingdom.
  • Graça G; Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, United Kingdom.
  • Chekmeneva E; Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA 6150, Australia.
  • Camuzeaux S; Perron Institute, Nedlands, WA 6009, Australia.
  • Lewis MR; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London SW7 2AZ, United Kingdom.
  • Kaluarachchi MR; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio 70210, Finland.
  • Ikram MA; Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London SW7 2AZ, United Kingdom.
  • Holmes E; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm 17177, Sweden.
  • Tzoulaki I; Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London SW7 2AZ, United Kingdom.
  • Matthews PM; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm 17177, Sweden.
  • Griffin JL; Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio 70210, Finland.
  • Elliott P; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm 17177, Sweden.
Proc Natl Acad Sci U S A ; 119(43): e2206083119, 2022 10 25.
Article em En | MEDLINE | ID: mdl-36269859
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ceramidas / Transportadores de Cassetes de Ligação de ATP / Doença de Alzheimer Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ceramidas / Transportadores de Cassetes de Ligação de ATP / Doença de Alzheimer Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido