Improving the Manufacturability of Cohesive and Poorly Compactable API for Direct Compression of Mini-tablets at High Drug Loading via Particle Engineering.

Chen, Liang; Lin, Yiqing; Irdam, Erwin; Madden, Nicole; Osei-Yeboah, Frederick

Chen, Liang; Lin, Yiqing; Irdam, Erwin; Madden, Nicole; Osei-Yeboah, Frederick.

Afiliação

Chen L; Small Molecule Drug Product Development, Biogen, 225 Binney St., Cambridge, Massachusetts, 02142, USA. liang.chen@biogen.com.
Lin Y; Small Molecule Drug Product Development, Biogen, 225 Binney St., Cambridge, Massachusetts, 02142, USA.
Irdam E; Small Molecule Drug Product Development, Biogen, 225 Binney St., Cambridge, Massachusetts, 02142, USA.
Madden N; Small Molecule Drug Product Development, Biogen, 225 Binney St., Cambridge, Massachusetts, 02142, USA.
Osei-Yeboah F; Small Molecule Drug Product Development, Biogen, 225 Binney St., Cambridge, Massachusetts, 02142, USA.

Pharm Res ; 39(12): 3185-3195, 2022 Dec.

Article em En | MEDLINE | ID: mdl-36319885

Assuntos

Composição de Medicamentos; Pós; Tamanho da Partícula; Pressão; Comprimidos

Palavras-chave

direct compression; flowability; particle engineering; tabletability; wet milling, mini-tablets

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Composição de Medicamentos Idioma: En Revista: Pharm Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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