Empagliflozin Induced Ketosis, Upregulated IGF-1/Insulin Receptors and the Canonical Insulin Signaling Pathway in Neurons, and Decreased the Excitatory Neurotransmitter Glutamate in the Brain of Non-Diabetics.

Avgerinos, Konstantinos I; Mullins, Roger J; Vreones, Michael; Mustapic, Maja; Chen, Qinghua; Melvin, Denise; Kapogiannis, Dimitrios; Egan, Josephine M

Avgerinos, Konstantinos I; Mullins, Roger J; Vreones, Michael; Mustapic, Maja; Chen, Qinghua; Melvin, Denise; Kapogiannis, Dimitrios; Egan, Josephine M.

Afiliação

Avgerinos KI; Laboratory of Clinical Investigation, Intramural Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Mullins RJ; Laboratory of Clinical Investigation, Intramural Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Vreones M; Laboratory of Clinical Investigation, Intramural Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Mustapic M; Laboratory of Clinical Investigation, Intramural Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Chen Q; Laboratory of Clinical Investigation, Intramural Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Melvin D; Laboratory of Clinical Investigation, Intramural Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Kapogiannis D; Laboratory of Clinical Investigation, Intramural Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Egan JM; Laboratory of Clinical Investigation, Intramural Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.

Cells ; 11(21)2022 10 25.

Article em En | MEDLINE | ID: mdl-36359767

Assuntos

Doença de Alzheimer; Diabetes Mellitus Tipo 2; Cetose; Inibidores do Transportador 2 de Sódio-Glicose; Feminino; Humanos; Pessoa de Meia-Idade; Doença de Alzheimer/metabolismo; Glicemia/metabolismo; Encéfalo/metabolismo; Diabetes Mellitus Tipo 2/tratamento farmacológico; Diabetes Mellitus Tipo 2/metabolismo; Ácido Glutâmico/metabolismo; Insulina/metabolismo; Insulina Regular Humana/metabolismo; Fator de Crescimento Insulin-Like I/metabolismo; Cetose/metabolismo; Neurônios/metabolismo; Neurotransmissores/metabolismo; Fator de Crescimento Placentário/metabolismo; Fator de Crescimento Placentário/farmacologia; Receptor de Insulina/metabolismo; Transdução de Sinais; Inibidores do Transportador 2 de Sódio-Glicose/farmacologia

Palavras-chave

empagliflozin; glutamate; glutamine; insulin signaling; magnetic resonance spectroscopy; neuronal-origin extracellular vesicles; ß-hydroxybutyrate

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Doença de Alzheimer / Inibidores do Transportador 2 de Sódio-Glicose / Cetose Limite: Female / Humans / Middle aged Idioma: En Revista: Cells Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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