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Mantle cell lymphoma involving the oral and maxillofacial region: a study of 20 cases.
Carvalho, Marcus Vinícius Ribeiro; Rodrigues-Fernandes, Carla Isabelly; de Cáceres, Cinthia Veronica Bardález López; Mesquita, Ricardo Alves; Martins, Manoela Domingues; Román Tager, Elena María José; Carlos, Roman; Pires, Fábio Ramôa; Robinson, Liam; van Heerden, Willie F P; Valente, Vitor Bonetti; Xavier-Júnior, José Cândido Caldeira; Bernabé, Daniel Galera; Pontes, Hélder Antônio Rebelo; Soares, Ciro Dantas; da Costa, Mauro Henrique Melo; Vargas, Pablo Agustin; Fonseca, Felipe Paiva.
Afiliação
  • Carvalho MVR; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
  • Rodrigues-Fernandes CI; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
  • de Cáceres CVBL; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
  • Mesquita RA; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Martins MD; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
  • Román Tager EMJ; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil; Pathology Section, Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Guatemala City, Guatemala.
  • Carlos R; Pathology Section, Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Guatemala City, Guatemala.
  • Pires FR; Oral Pathology, Dental School, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Robinson L; Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
  • van Heerden WFP; Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
  • Valente VB; Oral Oncology Center, São Paulo State University (UNESP), School of Dentistry, Araçatuba, Brazil.
  • Xavier-Júnior JCC; Pathology Institute of Araçatuba and School of Medicine, Centro Universitário Católico Unisalesiano Auxilium, Araçatuba, Brazil.
  • Bernabé DG; Oral Oncology Center, São Paulo State University (UNESP), School of Dentistry, Araçatuba, Brazil.
  • Pontes HAR; Oral Pathology Service, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil.
  • Soares CD; Getúlio Sales Diagnósticos, Natal, Brazil.
  • da Costa MHM; Private practice, Campinas, Brazil.
  • Vargas PA; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil; Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
  • Fonseca FP; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty
Oral Surg Oral Med Oral Pathol Oral Radiol ; 135(1): 101-109, 2023 01.
Article em En | MEDLINE | ID: mdl-36396588
ABSTRACT

OBJECTIVE:

To investigate the clinicopathologic features of mantle cell lymphoma (MCL) involving the oral and maxillofacial region.

METHODS:

The MCL cases were retrieved from the pathosis database of 6 pathology laboratories. Original hematoxylin and eosin slides and immunohistochemical reactions were reviewed for confirmation of the initial diagnosis. Clinical data of the cases were obtained from the patients' pathosis and/or medical charts.

RESULTS:

Twenty cases were included in the study, showing a male predominance and a mean age of 66 years. The oral cavity (12 cases) and the oropharynx (5 cases) were the most commonly involved subsites. Most cases presented as asymptomatic swellings, with 2 cases showing bilateral involvement of the palate. The classic histologic variant predominated (12/20 cases). All cases expressed CD20 with nuclear cyclin D1 positivity. SOX11 was seen in 9/13 cases, CD5 in 6/16 cases, Bcl2 in 16/19 cases, CD10 in 2/20 cases, and Bcl6 in 4/16 cases. Ki67 showed a mean proliferation index of 40.6%. The Epstein-Barr virus (EBV) was negative in all cases investigated. Follow-up data was available for 7 patients, with 5 currently alive and 2 deceased.

CONCLUSION:

Mantle cell lymphoma, albeit rare, may manifest in the oral and maxillofacial region. Its histologic heterogeneity demands a high degree of diagnostic skill from pathologists.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Vírus Epstein-Barr / Linfoma de Célula do Manto Limite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Oral Surg Oral Med Oral Pathol Oral Radiol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Vírus Epstein-Barr / Linfoma de Célula do Manto Limite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Oral Surg Oral Med Oral Pathol Oral Radiol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil