Physiology and pathology of the C3 amplification cycle: A retrospective.
Immunol Rev
; 313(1): 217-224, 2023 01.
Article
em En
| MEDLINE
| ID: mdl-36408746
ABSTRACT
The C3 "Tickover" hypothesis, a mechanism whereby the host maintains constant surveillance of potential invading pathogens, targeting them for elimination through amplified C3b generation and C3-dependent effector mechanisms, was proposed by the late Professor Peter Lachmann in 1973. This unique insight came from a combined understanding of the complement system as it was then defined and the nature of the disease process in rare complement deficiencies and complement-driven diseases. In this review, I give a personal perspective of how understanding of "Tickover" has developed in the subsequent 50 years, culminating in the introduction into the clinic of therapeutic agents designed to combat amplification-driven disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complemento C3
Limite:
Humans
Idioma:
En
Revista:
Immunol Rev
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Reino Unido