Targeting histone deacetylases in testicular germ cell tumours: an encouraging treatment approach for the future.
J Pathol
; 259(2): 115-118, 2023 02.
Article
em En
| MEDLINE
| ID: mdl-36426822
ABSTRACT
Epidrugs, specifically histone deacetylase inhibitors (HDACi), have been increasingly used in preclinical studies for the treatment of testicular germ cell tumours (TGCTs). SINHCAF was recently described as a potential oncogene in TGCTs located on chromosome 12p, the hallmark of type II (malignant) TGCTs. The findings contribute to the field by further supporting the efficacy of HDACi in the treatment of TGCTs, promoting the design of more preclinical studies and providing the motivation for future implementation of clinical studies with these compounds. © 2022 The Pathological Society of Great Britain and Ireland.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Testiculares
/
Neoplasias Embrionárias de Células Germinativas
Limite:
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Pathol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Portugal