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Structure-based design of bitopic ligands for the µ-opioid receptor.
Faouzi, Abdelfattah; Wang, Haoqing; Zaidi, Saheem A; DiBerto, Jeffrey F; Che, Tao; Qu, Qianhui; Robertson, Michael J; Madasu, Manish K; El Daibani, Amal; Varga, Balazs R; Zhang, Tiffany; Ruiz, Claudia; Liu, Shan; Xu, Jin; Appourchaux, Kevin; Slocum, Samuel T; Eans, Shainnel O; Cameron, Michael D; Al-Hasani, Ream; Pan, Ying Xian; Roth, Bryan L; McLaughlin, Jay P; Skiniotis, Georgios; Katritch, Vsevolod; Kobilka, Brian K; Majumdar, Susruta.
Afiliação
  • Faouzi A; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St Louis, MO, USA.
  • Wang H; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
  • Zaidi SA; Department of Quantitative and Computational Biology, Department of Chemistry, Bridge Institute and Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA.
  • DiBerto JF; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
  • Che T; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St Louis, MO, USA.
  • Qu Q; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
  • Robertson MJ; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
  • Madasu MK; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
  • El Daibani A; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
  • Varga BR; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
  • Zhang T; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St Louis, MO, USA.
  • Ruiz C; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St Louis, MO, USA.
  • Liu S; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St Louis, MO, USA.
  • Xu J; Department of Neurology and Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Appourchaux K; Department of Chemistry, Scripps Research, Jupiter, FL, USA.
  • Slocum ST; Department of Anesthesiology, Rutgers New Jersey Medical School, Newark, NJ, USA.
  • Eans SO; Department of Anesthesiology, Rutgers New Jersey Medical School, Newark, NJ, USA.
  • Cameron MD; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St Louis, MO, USA.
  • Al-Hasani R; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
  • Pan YX; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA.
  • Roth BL; Department of Chemistry, Scripps Research, Jupiter, FL, USA.
  • McLaughlin JP; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St Louis, MO, USA.
  • Skiniotis G; Department of Neurology and Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Katritch V; Department of Anesthesiology, Rutgers New Jersey Medical School, Newark, NJ, USA.
  • Kobilka BK; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
  • Majumdar S; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA.
Nature ; 613(7945): 767-774, 2023 01.
Article em En | MEDLINE | ID: mdl-36450356
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Fentanila / Receptores Opioides mu / Morfinanos Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Fentanila / Receptores Opioides mu / Morfinanos Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos