[Pharmacological analysis of the participation of ethanol-oxidizing enzyme systems in ethanol metabolism at different stages of experimental alcoholism]. / Farmakologicheskii analiz uchastiia otdel'nykh étanolokisliaiushchikh fermentnykh sistem v metabolizme étanola na raznykh stadiiakh éksperimental'nogo alkogolizma.

ABSTRACT

Using head space chromatography, the pharmacological analysis of changes in the activity of ethanol-oxidizing enzymatic systems alcohol dehydrogenase, catalase, microsomal ethanol-oxidizing system under the effect of pyrazole and aminotriazole, has been performed on the model of experimental alcoholism in rats. It was shown that the rate of ethanol elimination from the rats' blood at all stages of experimental alcoholism was determined by alcohol dehydrogenase, while catalase and microsomal ethanol-oxidizing system activities did not play an important role.