An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily.

Busa, Michal; Matousková, Zuzana; Bartosová-Sojková, Pavla; Pachl, Petr; Rezácová, Pavlína; Eichenberger, Ramon Marc; Deplazes, Peter; Horn, Martin; Stefanic, Sasa; Mares, Michael

Busa, Michal; Matousková, Zuzana; Bartosová-Sojková, Pavla; Pachl, Petr; Rezácová, Pavlína; Eichenberger, Ramon Marc; Deplazes, Peter; Horn, Martin; Stefanic, Sasa; Mares, Michael.

Afiliação

Busa M; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czechia; Department of Biochemistry, Faculty of Science, Charles University, Prague, Czechia.
Matousková Z; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czechia; Department of Biochemistry, Faculty of Science, Charles University, Prague, Czechia.
Bartosová-Sojková P; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Budweis, Czechia.
Pachl P; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czechia.
Rezácová P; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czechia.
Eichenberger RM; Institute of Parasitology, University of Zurich, Zurich, Switzerland.
Deplazes P; Institute of Parasitology, University of Zurich, Zurich, Switzerland.
Horn M; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czechia.
Stefanic S; Institute of Parasitology, University of Zurich, Zurich, Switzerland. Electronic address: sasa.stefanic@uzh.ch.
Mares M; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czechia. Electronic address: mares@uochb.cas.cz.

J Biol Chem ; 299(3): 102970, 2023 03.

Article em En | MEDLINE | ID: mdl-36736427

Assuntos

Cistatinas; Fasciola hepatica; Animais; Sequência de Aminoácidos; Cistatinas/genética; Cistatinas/química; Dissulfetos; Fasciola hepatica/genética; Filogenia; Proteínas de Helminto/química; Proteínas de Helminto/genética

Palavras-chave

cystatin; cysteine cathepsin; helminth parasite; protease inhibitor; protein evolution; protein structure; stefin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cistatinas / Fasciola hepatica Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2023 Tipo de documento: Article

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