Follow Your Nose: Repeat Nasal Bone Evaluation in First-Trimester Screening for Down Syndrome.
J Ultrasound Med
; 42(8): 1709-1716, 2023 Aug.
Article
em En
| MEDLINE
| ID: mdl-36744578
ABSTRACT
OBJECTIVE:
Examine whether repeat nasal bone evaluation following an absent/uncertain nasal bone on first-trimester screening (FTS) improves Down syndrome (DS) screening specificity.METHODS:
A retrospective chart review of FTS sonograms in one center from January 2015 to January 2018 was performed. Data was extracted for those with an absent/uncertain nasal bone. Repeat evaluations were offered.RESULTS:
Of 6780 FTS sonograms, 589 (8.7%) had an absent/uncertain nasal bone. Upon repeat exam, 268/376 (71.3%) had a present nasal bone. Compared with Black patients, patients of other ethnicities were more likely to have a present nasal bone on exam 2 (P < .00001). Of 268 patients with a present nasal bone on exam 2, 37 (13.8%) had an abnormal DS risk following exam 1; 34/37 (91.9%) normalized following nasal bone visualization, dropping the screen positive rate to 1.1%.CONCLUSION:
Repeat nasal bone examination is beneficial in refining DS risk assessment and improves the specificity of FTS.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Down
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
J Ultrasound Med
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos