Flipping Off and On the Redox Switch in the Microcirculation.
Annu Rev Physiol
; 85: 165-189, 2023 02 10.
Article
em En
| MEDLINE
| ID: mdl-36763969
ABSTRACT
Resistance arteries and arterioles evolved as specialized blood vessels serving two important functions (a) regulating peripheral vascular resistance and blood pressure and (b) matching oxygen and nutrient delivery to metabolic demands of organs. These functions require control of vessel lumen cross-sectional area (vascular tone) via coordinated vascular cell responses governed by precise spatial-temporal communication between intracellular signaling pathways. Herein, we provide a contemporary overview of the significant roles that redox switches play in calcium signaling for orchestrated endothelial, smooth muscle, and red blood cell control of arterial vascular tone. Three interrelated themes are the focus (a) smooth muscle to endothelial communication for vasoconstriction, (b) endothelial to smooth muscle cell cross talk for vasodilation, and (c) oxygen and red blood cell interregulation of vascular tone and blood flow. We intend for this thematic framework to highlight gaps in our current knowledge and potentially spark interest for cross-disciplinary studies moving forward.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vasoconstrição
/
Vasodilatação
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Physiol
Ano de publicação:
2023
Tipo de documento:
Article