Targeting of G-protein coupled receptor 40 alleviates airway hyperresponsiveness through RhoA/ROCK1 signaling pathway in obese asthmatic mice.

Lin, Xixi; Wang, Like; Lu, Xiaojie; Zhang, Yuanyuan; Zheng, Rongying; Chen, Ruijie; Zhang, Weixi

Lin, Xixi; Wang, Like; Lu, Xiaojie; Zhang, Yuanyuan; Zheng, Rongying; Chen, Ruijie; Zhang, Weixi.

Afiliação

Lin X; Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
Wang L; Department of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
Lu X; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
Zhang Y; Department of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
Zheng R; Department of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
Chen R; Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
Zhang W; Department of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China. zhangweixi112@wmu.edu.cn.

Respir Res ; 24(1): 56, 2023 Feb 17.

Article em En | MEDLINE | ID: mdl-36803977

Assuntos

Asma; Receptores Acoplados a Proteínas G; Hipersensibilidade Respiratória; Animais; Camundongos; Asma/metabolismo; Citocinas/metabolismo; Modelos Animais de Doenças; Pulmão/metabolismo; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Camundongos Obesos; Obesidade/metabolismo; Ovalbumina; Receptores Acoplados a Proteínas G/metabolismo; Hipersensibilidade Respiratória/metabolismo; Transdução de Sinais

Palavras-chave

Airway hyperresponsiveness; Asthma; GPR40; Obesity; RhoA/ROCK1

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipersensibilidade Respiratória / Asma / Receptores Acoplados a Proteínas G Limite: Animals Idioma: En Revista: Respir Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google