Design, synthesis, antimicrobial screening and molecular modeling of novel 6,7 dimethylquinoxalin-2(1H)-one and thiazole derivatives targeting DNA gyrase enzyme.

Alqurashi, Raghad M; Farghaly, Thoraya A; Sabour, Rehab; Shaabana, Mohamed R

Alqurashi, Raghad M; Farghaly, Thoraya A; Sabour, Rehab; Shaabana, Mohamed R.

Afiliação

Alqurashi RM; Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia.
Farghaly TA; Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia. Electronic address: tamohamed@uqu.edu.sa.
Sabour R; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Shaabana MR; Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.

Bioorg Chem ; 134: 106433, 2023 05.

Article em En | MEDLINE | ID: mdl-36842318

Assuntos

DNA Girase; Tiazóis; DNA Girase/metabolismo; Tiazóis/química; Simulação de Acoplamento Molecular; Staphylococcus aureus/metabolismo; Escherichia coli/metabolismo; Antibacterianos/química; Testes de Sensibilidade Microbiana; Inibidores da Topoisomerase II; Estrutura Molecular

Palavras-chave

6,7-dimethylquinoxalin-2(1H)-ones; Antimicrobial activity; DNA gyrase enzyme; Ethyl aroyl pyruvates; Thiazolone derivatives

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazóis / DNA Girase Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Revista: Bioorg Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Arábia Saudita

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