Your browser doesn't support javascript.
loading
Cancer neuroscience: State of the field, emerging directions.
Winkler, Frank; Venkatesh, Humsa S; Amit, Moran; Batchelor, Tracy; Demir, Ihsan Ekin; Deneen, Benjamin; Gutmann, David H; Hervey-Jumper, Shawn; Kuner, Thomas; Mabbott, Donald; Platten, Michael; Rolls, Asya; Sloan, Erica K; Wang, Timothy C; Wick, Wolfgang; Venkataramani, Varun; Monje, Michelle.
Afiliação
  • Winkler F; Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg and Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: frank.winkler@med.uni-heidelberg.de.
  • Venkatesh HS; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
  • Amit M; Department of Head and Neck Surgery, MD Anderson Cancer Center and The University of Texas Graduate School of Biomedical Sciences, Houston, TX, USA.
  • Batchelor T; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
  • Demir IE; Department of Surgery, Technical University of Munich, Munich, Germany.
  • Deneen B; Center for Stem Cells and Regenerative Medicine, Baylor College of Medicine, Houston, TX, USA.
  • Gutmann DH; Department of Neurology, Washington University, St Louis, MO, USA.
  • Hervey-Jumper S; Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
  • Kuner T; Department of Functional Neuroanatomy, University of Heidelberg, Heidelberg, Germany.
  • Mabbott D; Department of Psychology, University of Toronto and Neuroscience & Mental Health Program, Research Institute, The Hospital for Sick Children, Toronto, Canada.
  • Platten M; Department of Neurology, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
  • Rolls A; Department of Immunology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
  • Sloan EK; Monash Institute of Pharmaceutical Sciences, Drug Discovery Biology Theme, Monash University, Parkville, VIC, Australia.
  • Wang TC; Department of Medicine, Division of Digestive and Gastrointestinal Diseases, Columbia University, New York, NY, USA.
  • Wick W; Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg and Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Venkataramani V; Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg and Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Functional Neuroanatomy, University of Heidelberg, Heidelberg
  • Monje M; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA. Electronic address: mmonje@stanford.edu.
Cell ; 186(8): 1689-1707, 2023 04 13.
Article em En | MEDLINE | ID: mdl-37059069
ABSTRACT
The nervous system governs both ontogeny and oncology. Regulating organogenesis during development, maintaining homeostasis, and promoting plasticity throughout life, the nervous system plays parallel roles in the regulation of cancers. Foundational discoveries have elucidated direct paracrine and electrochemical communication between neurons and cancer cells, as well as indirect interactions through neural effects on the immune system and stromal cells in the tumor microenvironment in a wide range of malignancies. Nervous system-cancer interactions can regulate oncogenesis, growth, invasion and metastatic spread, treatment resistance, stimulation of tumor-promoting inflammation, and impairment of anti-cancer immunity. Progress in cancer neuroscience may create an important new pillar of cancer therapy.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neurociências / Neoplasias Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neurociências / Neoplasias Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2023 Tipo de documento: Article