Cellular stress induces non-canonical activation of the receptor tyrosine kinase EphA2 through the p38-MK2-RSK signaling pathway.

Zhou, Yue; Oki, Ryota; Tanaka, Akihiro; Song, Leixin; Takashima, Atsushi; Hamada, Naru; Yokoyama, Satoru; Yano, Seiji; Sakurai, Hiroaki

Zhou, Yue; Oki, Ryota; Tanaka, Akihiro; Song, Leixin; Takashima, Atsushi; Hamada, Naru; Yokoyama, Satoru; Yano, Seiji; Sakurai, Hiroaki.

Afiliação

Zhou Y; Department of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama; Toyama, Japan.
Oki R; Department of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama; Toyama, Japan.
Tanaka A; Department of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama; Toyama, Japan.
Song L; Department of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama; Toyama, Japan.
Takashima A; Department of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama; Toyama, Japan.
Hamada N; Department of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama; Toyama, Japan.
Yokoyama S; Department of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama; Toyama, Japan.
Yano S; Department of Respiratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan; Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan; WPI Nano Life Science Institute, Kanazawa Universit
Sakurai H; Department of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama; Toyama, Japan. Electronic address: hsakurai@pha.u-toyama.ac.jp.

J Biol Chem ; 299(5): 104699, 2023 05.

Article em En | MEDLINE | ID: mdl-37059179

Assuntos

Glioblastoma; Receptor EphA2; Transdução de Sinais; Humanos; Anisomicina/farmacologia; Movimento Celular; Cisplatino/farmacologia; Sistema de Sinalização das MAP Quinases/fisiologia; Pressão Osmótica; Fosforilação; Receptores Proteína Tirosina Quinases/metabolismo; Receptor EphA2/metabolismo; Proteínas Quinases S6 Ribossômicas 90-kDa/genética; Proteínas Quinases S6 Ribossômicas 90-kDa/metabolismo; Microambiente Tumoral

Palavras-chave

EphA2; MK2; RSK; cellular stress; migration; p38

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Glioblastoma / Receptor EphA2 Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão

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