Nanoscale nuclear environments, fine-scale 3D genome organization and transcription regulation.
Curr Opin Syst Biol
; 312022 Sep.
Article
em En
| MEDLINE
| ID: mdl-37091742
ABSTRACT
Decades of in vitro biochemical reconstitution, genetics and structural biology studies have established a vast knowledge base on the molecular mechanisms of chromatin regulation and transcription. A remaining challenge is to understand how these intricate biochemical systems operate in the context of the 3D genome organization and in the crowded and compartmentalized nuclear milieu. Here we review recent progress in this area based on high-resolution imaging approaches.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Curr Opin Syst Biol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos