M<sub>1</sub>-selective muscarinic allosteric modulation enhances cognitive flexibility and effective salience in nonhuman primates.

Hassani, Seyed A; Neumann, Adam; Russell, Jason; Jones, Carrie K; Womelsdorf, Thilo

M₁-selective muscarinic allosteric modulation enhances cognitive flexibility and effective salience in nonhuman primates.

Hassani, Seyed A; Neumann, Adam; Russell, Jason; Jones, Carrie K; Womelsdorf, Thilo.

Afiliação

Hassani SA; Department of Psychology, Vanderbilt University, Nashville, TN 37240.
Neumann A; Department of Psychology, Vanderbilt University, Nashville, TN 37240.
Russell J; Department of Pharmacology, Vanderbilt University, Nashville, TN 37240.
Jones CK; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37240.
Womelsdorf T; Department of Pharmacology, Vanderbilt University, Nashville, TN 37240.

Proc Natl Acad Sci U S A ; 120(18): e2216792120, 2023 05 02.

Article em En | MEDLINE | ID: mdl-37104474

Assuntos

Acetilcolinesterase; Doença de Alzheimer; Animais; Regulação Alostérica/fisiologia; Colinérgicos/farmacologia; Acetilcolina/farmacologia; Cognição; Doença de Alzheimer/tratamento farmacológico; Primatas; Receptor Muscarínico M1

Palavras-chave

acetylcholine; attention; cognitive control; donepezil; learning

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Doença de Alzheimer Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article

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