Confinement of unliganded EGFR by tetraspanin nanodomains gates EGFR ligand binding and signaling.

Sugiyama, Michael G; Brown, Aidan I; Vega-Lugo, Jesus; Borges, Jazlyn P; Scott, Andrew M; Jaqaman, Khuloud; Fairn, Gregory D; Antonescu, Costin N

Sugiyama, Michael G; Brown, Aidan I; Vega-Lugo, Jesus; Borges, Jazlyn P; Scott, Andrew M; Jaqaman, Khuloud; Fairn, Gregory D; Antonescu, Costin N.

Afiliação

Sugiyama MG; Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, ON, Canada.
Brown AI; Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada.
Vega-Lugo J; Department of Biophysics, UT Southwestern Medical Center, Dallas, TX, USA.
Borges JP; Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON, Canada.
Scott AM; Olivia Newton-John Cancer Research Institute, La Trobe University, Melbourne, VIC, Australia.
Jaqaman K; Department of Biophysics, UT Southwestern Medical Center, Dallas, TX, USA.
Fairn GD; Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.
Antonescu CN; Department of Pathology, Dalhousie University, Halifax, NS, Canada.

Nat Commun ; 14(1): 2681, 2023 05 09.

Article em En | MEDLINE | ID: mdl-37160944

Assuntos

Receptores ErbB; Transdução de Sinais; Ligantes; Fosforilação; Tetraspaninas

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Receptores ErbB Tipo de estudo: Prognostic_studies Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá

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