Paeonol, the active component of Cynanchum paniculatum, ameliorated schizophrenia-like behaviors by regulating the PI3K-Akt-GSK3ß-NF-&#954;B signalling pathway in MK-801-treated mice.

Bae, Ho Jung; Kim, Jae Youn; Choi, Seung-Hyuk; Kim, So-Yeon; Kim, Hyun-Jeong; Cho, Ye Eun; Choi, Yu-Yeong; An, Ju-Yeon; Cho, So-Young; Ryu, Jong Hoon; Park, Se Jin

Paeonol, the active component of Cynanchum paniculatum, ameliorated schizophrenia-like behaviors by regulating the PI3K-Akt-GSK3ß-NF-κB signalling pathway in MK-801-treated mice.

Bae, Ho Jung; Kim, Jae Youn; Choi, Seung-Hyuk; Kim, So-Yeon; Kim, Hyun-Jeong; Cho, Ye Eun; Choi, Yu-Yeong; An, Ju-Yeon; Cho, So-Young; Ryu, Jong Hoon; Park, Se Jin.

Afiliação

Bae HJ; Agriculture and Life Science Research Institute, Kangwon National University, Chuncheon, 24341, Republic of Korea. Electronic address: baehj321@kangwon.ac.kr.
Kim JY; Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea. Electronic address: kfc7745@khu.ac.kr.
Choi SH; Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341, Republic of Korea. Electronic address: chltmdgur96@kangwon.ac.kr.
Kim SY; Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341, Republic of Korea. Electronic address: ykims95@kangwon.ac.kr.
Kim HJ; Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341, Republic of Korea. Electronic address: hjkim0702@kangwon.ac.kr.
Cho YE; Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341, Republic of Korea. Electronic address: 202215525@kangwon.ac.kr.
Choi YY; Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341, Republic of Korea. Electronic address: tyler441@kangwon.ac.kr.
An JY; Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341, Republic of Korea. Electronic address: anjuyeon0907@kangwon.ac.kr.
Cho SY; Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341, Republic of Korea. Electronic address: whthdud67@kangwon.ac.kr.
Ryu JH; Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea. Electronic address: jhryu63@khu.ac.kr.
Park SJ; Agriculture and Life Science Research Institute, Kangwon National University, Chuncheon, 24341, Republic of Korea; Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341, Republic of Korea; School of Natural Resources and Environmental Sciences, Kangwon National

J Ethnopharmacol ; 314: 116627, 2023 Oct 05.

Article em En | MEDLINE | ID: mdl-37164258

Assuntos

Cynanchum; Esquizofrenia; Animais; Camundongos; NF-kappa B/metabolismo; Maleato de Dizocilpina; Proteínas Proto-Oncogênicas c-akt/metabolismo; Fosfatidilinositol 3-Quinases; Reflexo de Sobressalto; Esquizofrenia/induzido quimicamente; Esquizofrenia/tratamento farmacológico; Esquizofrenia/metabolismo; Glicogênio Sintase Quinase 3 beta

Palavras-chave

Cynanchum paniculatum; Paeonol; Prepulse inhibition; Schizophrenia; Social interaction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Cynanchum Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2023 Tipo de documento: Article

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