In vivo infection dynamics and human adaptive changes of SIVsm-derived viral siblings SIVmac239, SIV<sub>B670</sub> and SIVhu in humanized mice as a paralog of HIV-2 genesis.

Curlin, James Z; Schmitt, Kimberly; Remling-Mulder, Leila; Moriarty, Ryan; Baczenas, John J; Goff, Kelly; O'Connor, Shelby; Stenglein, Mark; Marx, Preston A; Akkina, Ramesh

In vivo infection dynamics and human adaptive changes of SIVsm-derived viral siblings SIVmac239, SIV_B670 and SIVhu in humanized mice as a paralog of HIV-2 genesis.

Curlin, James Z; Schmitt, Kimberly; Remling-Mulder, Leila; Moriarty, Ryan; Baczenas, John J; Goff, Kelly; O'Connor, Shelby; Stenglein, Mark; Marx, Preston A; Akkina, Ramesh.

Afiliação

Curlin JZ; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Schmitt K; Antiviral Discovery, Evaluation and Application Research (ADEAR) Training Program, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Remling-Mulder L; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Moriarty R; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Baczenas JJ; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Goff K; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
O'Connor S; Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Stenglein M; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Marx PA; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Akkina R; Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.

Front Virol ; 12021.

Article em En | MEDLINE | ID: mdl-37168442

Palavras-chave

A dual purpose humanized mouse model for HIV and SIV research; HIV origins and evolution from SIV; SIV cross-species transmission; SIV evolution into HIV-2; SIVmac and SIVB670 pathogenesis and evolution in humanized mice; origin of human pathogens in NHP; origins of human pandemic viruses; viral adaptive changes and evolution

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Virol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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