Kinetics of Water-Induced Amorphous Phase Separation in Amorphous Solid Dispersions via Raman Mapping.

Krummnow, Adrian; Danzer, Andreas; Voges, Kristin; Kyeremateng, Samuel O; Degenhardt, Matthias; Sadowski, Gabriele

Krummnow, Adrian; Danzer, Andreas; Voges, Kristin; Kyeremateng, Samuel O; Degenhardt, Matthias; Sadowski, Gabriele.

Afiliação

Krummnow A; Laboratory of Thermodynamics, Department of Biochemical and Chemical Engineering, TU Dortmund University, Emil-Figge-Street 70, D-44227 Dortmund, Germany.
Danzer A; AbbVie Deutschland GmbH & Co. KG, Global Pharmaceutical R&D, Knollstraße, D-67061 Ludwigshafen am Rhein, Germany.
Voges K; Laboratory of Thermodynamics, Department of Biochemical and Chemical Engineering, TU Dortmund University, Emil-Figge-Street 70, D-44227 Dortmund, Germany.
Kyeremateng SO; AbbVie Deutschland GmbH & Co. KG, Global Pharmaceutical R&D, Knollstraße, D-67061 Ludwigshafen am Rhein, Germany.
Degenhardt M; AbbVie Deutschland GmbH & Co. KG, Global Pharmaceutical R&D, Knollstraße, D-67061 Ludwigshafen am Rhein, Germany.
Sadowski G; AbbVie Deutschland GmbH & Co. KG, Global Pharmaceutical R&D, Knollstraße, D-67061 Ludwigshafen am Rhein, Germany.

Pharmaceutics ; 15(5)2023 May 02.

Article em En | MEDLINE | ID: mdl-37242637

Palavras-chave

Raman imaging; amorphous phase separation; confocal Raman spectroscopy; copovidone; kinetics; miscibility gap; phase behavior

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Pharmaceutics Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha

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