[Characteristics of allergen component in dust mite-induced allergic rhinitis patients].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
; 37(6): 442-447, 2023 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-37253517
ABSTRACT
Objective:
To investigate the characteristics of allergen component in dust miteï¼DMï¼ -induced allergic rhinitisï¼ARï¼ patients, and provide reference for the diagnosis and treatment of AR.Methods:
DM-induced AR patients with or without allergic asthmaï¼AAï¼ who visited the Allergy Department of Tongji Hospital, Huazhong University of Science and Technology between 2021 and 2022 were enrolled. Patients'age, gender, and visual analog scaleï¼VASï¼ for symptoms were recorded. sIgE and sIgG4 levels of allergen components such as Der f1, Der f2, Der p1, Der p2, Der p7, Der p10, Der p21, and Der p23 were detected using a protein chip method. The sensitization characteristics of the allergen components in the patients were observed, and the correlation between sIgE, sIgG of each component and VAS as well as the component differences between AR and AR with AAï¼AR&AAï¼ were evaluated.Results:
A total of 87 DM-induced AR patients were enrolled, with 42.5% of them were AR&AA, their VAS scores were significantly higher than those of AR patientsï¼6.38±1.95 vs 5.25±1.85, P=0.009 8ï¼. The order of sensitization rates for DM components was as follows Der p2ï¼82.8%ï¼, Der f2ï¼81.6%ï¼, Der p1ï¼74.7%ï¼, Der f1ï¼70.1%ï¼, and Der p23ï¼35.6%ï¼. The order of positive rates for sIgG4 was Der p2ï¼21.8%ï¼, Der f2ï¼13.8%ï¼, Der p21ï¼8.0%ï¼, and Der p7ï¼6.9%ï¼. There were no correlation between the sIgE, sIgG4 levels or positive numbers of components and VAS scores, but there were positive correlations between sIgE, sIgG4 concentrations of components. Compared with AR patients, AR&AA patients had higher levels of sIgE for Der pï¼60.5[7.2-91.1]vs 14.0[4.8-45.1], P=0.02ï¼, Der fï¼49.8[15.7-81.6]vs 21.3[7.0-50.2], P=0.04ï¼, Der p1ï¼27.2[0.7-51.5]vs 2.6[0.2-24.9], P=0.02ï¼, Der p2ï¼20.0[1.4-60.6]vs 5.5[0.6-19.1], P=0.004ï¼, and Der f2ï¼58.9[16.0-89.2]vs 23.4[0.9-56.8], P=0.009ï¼, and a higher proportion of AR with AA patients had sIgE levels of Der p1ï¼70.3% vs 48.0%, P=0.038ï¼ and Der p23ï¼27.0% vs 14.0%, P=0.039ï¼ that were ≥3 grades.Conclusion:
Der p1/f1, Der p2/f3, and Der p23 are the major components of DM sensitized AR patients. Multiple component sensitization and sIgE, sIgG4 levels of each component are not correlated with the severity of AR. The sIgE levels of the Der p1/f1, Der p2/f3, and Der p23 components in AR&AA patients are higher than AR.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Rinite Alérgica
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Ano de publicação:
2023
Tipo de documento:
Article