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South Asian medical cohorts reveal strong founder effects and high rates of homozygosity.
Wall, Jeffrey D; Sathirapongsasuti, J Fah; Gupta, Ravi; Rasheed, Asif; Venkatesan, Radha; Belsare, Saurabh; Menon, Ramesh; Phalke, Sameer; Mittal, Anuradha; Fang, John; Tanneeru, Deepak; Deshmukh, Manjari; Bassi, Akshi; Robinson, Jacqueline; Chaudhary, Ruchi; Murugan, Sakthivel; Ul-Asar, Zameer; Saleem, Imran; Ishtiaq, Unzila; Fatima, Areej; Sheikh, Saqib Shafi; Hameed, Shahid; Ishaq, Mohammad; Rasheed, Syed Zahed; Memon, Fazal-Ur-Rehman; Jalal, Anjum; Abbas, Shahid; Frossard, Philippe; Fuchsberger, Christian; Forer, Lukas; Schoenherr, Sebastian; Bei, Qixin; Bhangale, Tushar; Tom, Jennifer; Gadde, Santosh Gopi Krishna; B V, Priya; Naik, Naveen Kumar; Wang, Minxian; Kwok, Pui-Yan; Khera, Amit V; Lakshmi, B R; Butterworth, Adam S; Chowdhury, Rajiv; Danesh, John; di Angelantonio, Emanuele; Naheed, Aliya; Goyal, Vinay; Kandadai, Rukmini M; Kumar, Hrishikesh; Borgohain, Rupam.
Afiliação
  • Wall JD; Institute for Human Genetics, University of California, San Francisco, CA, 94143, USA. jeffwall.genetics@gmail.com.
  • Sathirapongsasuti JF; Dept of Ornithology and Mammology, California Academy of Sciences, San Francisco, CA, 94118, USA. jeffwall.genetics@gmail.com.
  • Gupta R; MedGenome Inc., Foster City, CA, 94404, USA.
  • Rasheed A; GenomeAsia 100K Foundation, Foster City, CA, 94404, USA.
  • Venkatesan R; MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, 560099, India.
  • Belsare S; Center for Non-Communicable Disease, Karachi, Karachi City, Sindh, 75300, Pakistan.
  • Menon R; Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialties Centre, Chennai, Tamil Nadu, 600086, India.
  • Phalke S; Institute for Human Genetics, University of California, San Francisco, CA, 94143, USA.
  • Mittal A; MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, 560099, India.
  • Fang J; MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, 560099, India.
  • Tanneeru D; Thermo Fisher Scientific, Santa Clara, CA, 95051, USA.
  • Deshmukh M; Thermo Fisher Scientific, Santa Clara, CA, 95051, USA.
  • Bassi A; MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, 560099, India.
  • Robinson J; MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, 560099, India.
  • Chaudhary R; MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, 560099, India.
  • Murugan S; Institute for Human Genetics, University of California, San Francisco, CA, 94143, USA.
  • Ul-Asar Z; MedGenome Inc., Foster City, CA, 94404, USA.
  • Saleem I; MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, 560099, India.
  • Ishtiaq U; Center for Non-Communicable Disease, Karachi, Karachi City, Sindh, 75300, Pakistan.
  • Fatima A; Center for Non-Communicable Disease, Karachi, Karachi City, Sindh, 75300, Pakistan.
  • Sheikh SS; Center for Non-Communicable Disease, Karachi, Karachi City, Sindh, 75300, Pakistan.
  • Hameed S; Center for Non-Communicable Disease, Karachi, Karachi City, Sindh, 75300, Pakistan.
  • Ishaq M; Punjab Institute of Cardiology, Lahore, Pakistan.
  • Rasheed SZ; Punjab Institute of Cardiology, Lahore, Pakistan.
  • Memon FU; Karachi Institute of Heart Diseases, Karachi, Pakistan.
  • Jalal A; Karachi Institute of Heart Diseases, Karachi, Pakistan.
  • Abbas S; Red Crescent Institute of Cardiology, Hyderabad, Pakistan.
  • Frossard P; Faisalabad Institute of Cardiology, Faisalabad, Pakistan.
  • Fuchsberger C; Faisalabad Institute of Cardiology, Faisalabad, Pakistan.
  • Forer L; Center for Non-Communicable Disease, Karachi, Karachi City, Sindh, 75300, Pakistan.
  • Schoenherr S; Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.
  • Bei Q; Institute for Biomedicine, Eurac Research, Bolzano, Italy.
  • Bhangale T; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
  • Tom J; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
  • Gadde SGK; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
  • B V P; Department of Molecular Biology, Genentech, South San Francisco, CA, 94080, USA.
  • Naik NK; Department of Human Genetics, Genentech, South San Francisco, CA, 94080, USA.
  • Wang M; Product Development Data Sciences, Genentech, South San Francisco, CA, 94080, USA.
  • Kwok PY; Narayana Nethralaya Foundation, Bengaluru, Karnataka, 560010, India.
  • Khera AV; Narayana Nethralaya Foundation, Bengaluru, Karnataka, 560010, India.
  • Lakshmi BR; Narayana Nethralaya Foundation, Bengaluru, Karnataka, 560010, India.
  • Butterworth AS; Program in Medical and Population Genetics & Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Chowdhury R; Institute for Human Genetics, University of California, San Francisco, CA, 94143, USA.
  • Danesh J; Cardiovascular Research Institute and Department of Dermatology, University of California San Francisco, San Francisco, CA, 94143, USA.
  • di Angelantonio E; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  • Naheed A; Harvard Medical School, Boston, MA, 02115, USA.
  • Goyal V; Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, MA, 02115, Boston, USA.
  • Kandadai RM; Verve Therapeutics, Cambridge, MA, 02139, USA.
  • Kumar H; MDCRC, Royal Care Super Speciality Hospital 1/520, Neelambur, Coimbatore, Tamil Nadu, 641062, India.
  • Borgohain R; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Nat Commun ; 14(1): 3377, 2023 06 08.
Article em En | MEDLINE | ID: mdl-37291107
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeito Fundador / Povo Asiático Tipo de estudo: Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeito Fundador / Povo Asiático Tipo de estudo: Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos