Coronaridine congeners induce sedative and anxiolytic-like activity in naïve and stressed/anxious mice by allosteric mechanisms involving increased GABA<sub>A</sub> receptor affinity for GABA.

Arias, Hugo R; De Deurwaerdère, Philippe; Scholze, Petra; Sakamoto, Seiji; Hamachi, Itaru; Di Giovanni, Giuseppe; Chagraoui, Abdeslam

Coronaridine congeners induce sedative and anxiolytic-like activity in naïve and stressed/anxious mice by allosteric mechanisms involving increased GABA_A receptor affinity for GABA.

Arias, Hugo R; De Deurwaerdère, Philippe; Scholze, Petra; Sakamoto, Seiji; Hamachi, Itaru; Di Giovanni, Giuseppe; Chagraoui, Abdeslam.

Afiliação

Arias HR; Department of Pharmacology and Physiology, Oklahoma State University College of Osteopathic Medicine, Tahlequah, OK, USA.
De Deurwaerdère P; Centre National de la Recherche Scientifique, Institut des Neurosciences Intégratives et Cognitives d'Aquitaine, UMR, 5287, Bordeaux, France.
Scholze P; Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Sakamoto S; Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
Hamachi I; Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
Di Giovanni G; Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta; Neuroscience Division, School of Biosciences, Cardiff University, Cardiff, United Kingdom.
Chagraoui A; Department of Medical Biochemistry, Rouen University Hospital, CHU de Rouen, France; Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Normandie University, UNIROUEN, INSERM U1239, Institute for Research and Innovation in Biomedicine of Normandy (IRIB) Rouen, France. Elect

Eur J Pharmacol ; 953: 175854, 2023 Aug 15.

Article em En | MEDLINE | ID: mdl-37331683

Assuntos

Ansiolíticos; Camundongos; Masculino; Feminino; Animais; Ansiolíticos/farmacologia; Hipnóticos e Sedativos/farmacologia; Receptores de GABA-A/metabolismo; Pentilenotetrazol; Benzodiazepinas/farmacologia; Ácido gama-Aminobutírico/farmacologia

Palavras-chave

Anxiolytic activity; Coronaridine congeners; Fluorescence; GABAA receptors; Radioligand; Sedative activity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiolíticos Limite: Animals Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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