Inhibition of PERK Kinase, an Orchestrator of the Unfolded Protein Response (UPR), Significantly Reduces Apoptosis and Inflammation of Lung Epithelial Cells Triggered by SARS-CoV-2 ORF3a Protein.

Keramidas, Panagiotis; Papachristou, Eleni; Papi, Rigini M; Mantsou, Aglaia; Choli-Papadopoulou, Theodora

Keramidas, Panagiotis; Papachristou, Eleni; Papi, Rigini M; Mantsou, Aglaia; Choli-Papadopoulou, Theodora.

Afiliação

Keramidas P; Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.
Papachristou E; Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.
Papi RM; Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.
Mantsou A; Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.
Choli-Papadopoulou T; Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.

Biomedicines ; 11(6)2023 May 30.

Article em En | MEDLINE | ID: mdl-37371681

Palavras-chave

ER stress; GSK2606414; ORF3a; PERK; SARS-CoV-2; apoptosis; cytokine storm; inflammation; pyroptosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biomedicines Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Grécia

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