USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice.

Li, Xingguo; Zhang, Jun; Wang, Bing; Chen, Chao; Zhang, Enyu; Lv, Zhengpin; He, Qicong; Hu, Yaoquan; Wang, Xuenan; Zhang, Fan

Li, Xingguo; Zhang, Jun; Wang, Bing; Chen, Chao; Zhang, Enyu; Lv, Zhengpin; He, Qicong; Hu, Yaoquan; Wang, Xuenan; Zhang, Fan.

Afiliação

Li X; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Zhang J; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Wang B; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Chen C; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Zhang E; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Lv Z; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
He Q; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Hu Y; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Wang X; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Zhang F; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China. zhangfan4@kmmu.edu.cn.

Biol Direct ; 18(1): 37, 2023 07 06.

Article em En | MEDLINE | ID: mdl-37415159

Assuntos

Degeneração do Disco Intervertebral; Disco Intervertebral; Camundongos; Animais; Coativador 3 de Receptor Nuclear/metabolismo; Disco Intervertebral/metabolismo; Disco Intervertebral/patologia; Degeneração do Disco Intervertebral/genética; Degeneração do Disco Intervertebral/metabolismo; Degeneração do Disco Intervertebral/patologia; Inflamação/genética; Matriz Extracelular/metabolismo; Matriz Extracelular/patologia; Subunidade alfa 1 de Fator de Ligação ao Core/genética; Subunidade alfa 1 de Fator de Ligação ao Core/metabolismo

Palavras-chave

ADAMTS; Chronic inflammation; NCOA3; Runx2; USP24; p300

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Degeneração do Disco Intervertebral / Disco Intervertebral Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biol Direct Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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