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Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function.
Coleman, Oliver D; Macdonald, Jessica; Thomson, Ben; Ward, Jennifer A; Stubbs, Christopher J; McAllister, Tom E; Clark, Shane; Amin, Siddique; Cao, Yimang; Abboud, Martine I; Zhang, Yijia; Sanganee, Hitesh; Huber, Kilian V M; Claridge, Tim D W; Kawamura, Akane.
Afiliação
  • Coleman OD; School of Natural and Environmental Sciences - Chemistry, Newcastle University Newcastle NE1 7RU UK akane.kawamura@ncl.ac.uk.
  • Macdonald J; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk.
  • Thomson B; Radcliffe Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford Roosevelt Drive Old Road Campus Oxford OX3 7BN UK.
  • Ward JA; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk.
  • Stubbs CJ; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk.
  • McAllister TE; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford Old Road Campus Oxford OX3 7FZ UK.
  • Clark S; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford Oxford OX3 7FZ UK.
  • Amin S; Mechanistic and Structural Biology, Discovery Sciences, R&D, AstraZeneca Cambridge CB4 0WG UK.
  • Cao Y; School of Natural and Environmental Sciences - Chemistry, Newcastle University Newcastle NE1 7RU UK akane.kawamura@ncl.ac.uk.
  • Abboud MI; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk.
  • Zhang Y; Radcliffe Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford Roosevelt Drive Old Road Campus Oxford OX3 7BN UK.
  • Sanganee H; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk.
  • Huber KVM; School of Natural and Environmental Sciences - Chemistry, Newcastle University Newcastle NE1 7RU UK akane.kawamura@ncl.ac.uk.
  • Claridge TDW; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk.
  • Kawamura A; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk.
Chem Sci ; 14(26): 7136-7146, 2023 Jul 05.
Article em En | MEDLINE | ID: mdl-37416723
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chem Sci Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chem Sci Ano de publicação: 2023 Tipo de documento: Article