Sequential Azidation/Azolation of Prenylated Derivatives and a Click Reaction Enable Selective Labeling and Degradation of RAS Protein.

Gan, Youfang; Chen, Xiaoqian; Li, Yuanyuan; Guo, Yuyang; Wang, Rui

Gan, Youfang; Chen, Xiaoqian; Li, Yuanyuan; Guo, Yuyang; Wang, Rui.

Afiliação

Gan Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Chen X; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Li Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Guo Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Wang R; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

J Org Chem ; 88(15): 10836-10843, 2023 08 04.

Article em En | MEDLINE | ID: mdl-37462271

Assuntos

Proteínas ras; Células HeLa

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas ras Idioma: En Revista: J Org Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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