1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding.

Hamid, Rawia; Adam, Sebastian; Lacour, Antoine; Monjas, Leticia; Köhnke, Jesko; Hirsch, Anna K H

Hamid, Rawia; Adam, Sebastian; Lacour, Antoine; Monjas, Leticia; Köhnke, Jesko; Hirsch, Anna K H.

Afiliação

Hamid R; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany; Department of Pharmacy, Saarland University, Saarbrücken, Germany.
Adam S; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany.
Lacour A; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany.
Monjas L; Stratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands.
Köhnke J; Institute of Food Chemistry, Leibniz University Hannover, Hannover, Germany; School of Chemistry, University of Glasgow, Glasgow, UK.
Hirsch AKH; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany; Department of Pharmacy, Saarland University, Saarbrücken, Germany. Electronic address: anna.hirsch@helmholtz-hips.de.

J Biol Chem ; 299(9): 105152, 2023 09.

Article em En | MEDLINE | ID: mdl-37567475

Assuntos

Coenzimas; Klebsiella pneumoniae; Pseudomonas aeruginosa; Transferases; Humanos; Antibacterianos/farmacologia; Klebsiella pneumoniae/efeitos dos fármacos; Klebsiella pneumoniae/enzimologia; Pseudomonas aeruginosa/efeitos dos fármacos; Pseudomonas aeruginosa/enzimologia; Transferases/química; Transferases/metabolismo; Conformação Proteica; Coenzimas/metabolismo; Vitamina B 6/biossíntese; Tiamina/biossíntese; Apoenzimas/química; Apoenzimas/metabolismo; Tiamina Pirofosfato/metabolismo; Domínio Catalítico; Farmacorresistência Bacteriana

Palavras-chave

1-deoxy-D-xylulose 5-phosphate synthase; DXPS; Klebsiella pneumonia; Pseudomonas aeruginosa; X-ray crystallography; conformational changes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Transferases / Coenzimas / Klebsiella pneumoniae Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha

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