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Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti.
De Vita, Daniela; Frezza, Claudio; Sciubba, Fabio; Toniolo, Chiara; Badiali, Camilla; Petrucci, Rita; Bortolami, Martina; Di Matteo, Paola; Rocco, Daniele; Stringaro, Annarita; Colone, Marisa; Maxia, Andrea; Petrucci, Maria Teresa; Serafini, Mauro; Foddai, Sebastiano.
Afiliação
  • De Vita D; Department of Environmental Biology, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Frezza C; Department of Environmental Biology, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Sciubba F; Department of Environmental Biology, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Toniolo C; NMR-Based Metabolomics Laboratory, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Badiali C; Department of Environmental Biology, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Petrucci R; Department of Environmental Biology, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Bortolami M; Department of Basic and Applied Sciences for Engineering, "Sapienza" University of Rome, Via Castro Laurenziano 7, 00161 Rome, Italy.
  • Di Matteo P; Department of Basic and Applied Sciences for Engineering, "Sapienza" University of Rome, Via Castro Laurenziano 7, 00161 Rome, Italy.
  • Rocco D; Department of Basic and Applied Sciences for Engineering, "Sapienza" University of Rome, Via Castro Laurenziano 7, 00161 Rome, Italy.
  • Stringaro A; Department of Basic and Applied Sciences for Engineering, "Sapienza" University of Rome, Via Castro Laurenziano 7, 00161 Rome, Italy.
  • Colone M; National Center for Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy.
  • Maxia A; National Center for Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy.
  • Petrucci MT; Laboratory of Economic and Pharmaceutical Botany, Department of Life and Environmental Sciences, University of Cagliari, Viale S. Ignazio da Laconi 13, 09123 Cagliari, Italy.
  • Serafini M; Department of Cellular Biotechnologies and Hematology, "Sapienza" University of Rome, Via Benevento 6, 00161 Rome, Italy.
  • Foddai S; Department of Environmental Biology, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Molecules ; 28(15)2023 Jul 25.
Article em En | MEDLINE | ID: mdl-37570609
ABSTRACT
Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B15) of V. sardoa alkaloid-rich extracts obtained from plants grown in Italy, in Iglesias (Sardinia) and Rome (Latium). All the extracts showed a good capacity to induce reductions in cell proliferation of up to 50% at the tested concentrations (1-15 µg/mL). Moreover, none of the extracts showed cytotoxicity on normal cells at all the studied concentrations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vinca / Alcaloides / Antineoplásicos Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vinca / Alcaloides / Antineoplásicos Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália