Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters.
Trends Biochem Sci
; 48(10): 839-848, 2023 10.
Article
em En
| MEDLINE
| ID: mdl-37574371
ABSTRACT
Core promoters are sites where transcriptional regulatory inputs of a gene are integrated to direct the assembly of the preinitiation complex (PIC) and RNA polymerase II (Pol II) transcription output. Until now, core promoter functions have been investigated by distinct methods, including Pol II transcription initiation site mappings and structural characterization of PICs on distinct promoters. Here, we bring together these previously unconnected observations and hypothesize how, on metazoan TATA promoters, the precisely structured building up of transcription factor (TF) IID-based PICs results in sharp transcription start site (TSS) selection; or, in contrast, how the less strictly controlled positioning of the TATA-less promoter DNA relative to TFIID-core PIC components results in alternative broad TSS selections by Pol II.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Fator de Transcrição TFIID
Limite:
Animals
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2023
Tipo de documento:
Article