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Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS.
Schulze, Christopher J; Seamon, Kyle J; Zhao, Yulei; Yang, Yu C; Cregg, Jim; Kim, Dongsung; Tomlinson, Aidan; Choy, Tiffany J; Wang, Zhican; Sang, Ben; Pourfarjam, Yasin; Lucas, Jessica; Cuevas-Navarro, Antonio; Ayala-Santos, Carlos; Vides, Alberto; Li, Chuanchuan; Marquez, Abby; Zhong, Mengqi; Vemulapalli, Vidyasiri; Weller, Caroline; Gould, Andrea; Whalen, Daniel M; Salvador, Anthony; Milin, Anthony; Saldajeno-Concar, Mae; Dinglasan, Nuntana; Chen, Anqi; Evans, Jim; Knox, John E; Koltun, Elena S; Singh, Mallika; Nichols, Robert; Wildes, David; Gill, Adrian L; Smith, Jacqueline A M; Lito, Piro.
Afiliação
  • Schulze CJ; Department of Biology, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Seamon KJ; Department of Biology, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Zhao Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY 10065, USA.
  • Yang YC; Department of Biology, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Cregg J; Department of Discovery Chemistry, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Kim D; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY 10065, USA.
  • Tomlinson A; Department of Discovery Chemistry, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Choy TJ; Department of Biology, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Wang Z; Department of Non-clinical Development and Clinical Pharmacology, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Sang B; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY 10065, USA.
  • Pourfarjam Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY 10065, USA.
  • Lucas J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY 10065, USA.
  • Cuevas-Navarro A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY 10065, USA.
  • Ayala-Santos C; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY 10065, USA.
  • Vides A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY 10065, USA.
  • Li C; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY 10065, USA.
  • Marquez A; Department of Discovery Chemistry, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Zhong M; Department of Discovery Chemistry, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Vemulapalli V; Department of Biology, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Weller C; Department of Biology, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Gould A; Department of Biology, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Whalen DM; Department of Discovery Chemistry, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Salvador A; Department of Discovery Chemistry, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Milin A; Department of Discovery Chemistry, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Saldajeno-Concar M; Department of Discovery Chemistry, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Dinglasan N; Department of Biology, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Chen A; Department of Discovery Chemistry, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Evans J; Department of Biology, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Knox JE; Department of Discovery Chemistry, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Koltun ES; Department of Discovery Chemistry, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Singh M; Department of Biology, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Nichols R; Department of Biology, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Wildes D; Department of Biology, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Gill AL; Department of Discovery Chemistry, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Smith JAM; Department of Biology, Revolution Medicines, Inc., Redwood City, CA 94063, USA.
  • Lito P; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY 10065, USA.
Science ; 381(6659): 794-799, 2023 08 18.
Article em En | MEDLINE | ID: mdl-37590355
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Proteínas Proto-Oncogênicas p21(ras) / Chaperonas Moleculares / Imunofilinas / Ciclofilina A / Neoplasias Limite: Humans Idioma: En Revista: Science Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Proteínas Proto-Oncogênicas p21(ras) / Chaperonas Moleculares / Imunofilinas / Ciclofilina A / Neoplasias Limite: Humans Idioma: En Revista: Science Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos