Down-regulation of the mitochondrial fusion protein Opa1/Mfn2 promotes cardiomyocyte hypertrophy in Su5416/hypoxia-induced pulmonary hypertension rats.

Luo, Fangmei; Fu, Minyi; Wang, Ting; Qi, Yanan; Zhong, Xuefeng; Li, Dai; Liu, Bin

Luo, Fangmei; Fu, Minyi; Wang, Ting; Qi, Yanan; Zhong, Xuefeng; Li, Dai; Liu, Bin.

Afiliação

Luo F; Department of Pharmacy, Hunan Children's Hospital, Changsha, 410007, China.
Fu M; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China; Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China; The Hunan Institute of Ph
Wang T; Department of Pharmacy, Hunan Children's Hospital, Changsha, 410007, China.
Qi Y; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China.
Zhong X; Phase â Clinical Trial Center, Xiangya Hospital, Central South University, Changsha, 410008, China.
Li D; Phase â Clinical Trial Center, Xiangya Hospital, Central South University, Changsha, 410008, China.
Liu B; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China; Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China; The Hunan Institute of Ph

Arch Biochem Biophys ; 747: 109743, 2023 10 01.

Article em En | MEDLINE | ID: mdl-37696382

Assuntos

Hipertensão Pulmonar; Ratos; Animais; Hipertensão Pulmonar/induzido quimicamente; Hipertensão Pulmonar/genética; Miócitos Cardíacos/metabolismo; Dinâmica Mitocondrial; Regulação para Baixo; Proteínas Mitocondriais/metabolismo; Mitocôndrias/metabolismo; Hidrolases/metabolismo; Hipóxia/complicações; Hipóxia/metabolismo; Hipertrofia/complicações; Hipertrofia/metabolismo; Hipertrofia/patologia; Remodelação Ventricular; GTP Fosfo-Hidrolases/genética; GTP Fosfo-Hidrolases/metabolismo

Palavras-chave

Maladaptive right ventricular remodeling; Mitochondria-associated endoplasmic reticulum membranes; Mitochondrial dynamics; Mitofusin 2; Optic atrophy 1; Pulmonary hypertension

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipertensão Pulmonar Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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