Lung erosion following adjuvant immunotherapy with pembrolizumab: a case report.
J Med Case Rep
; 17(1): 420, 2023 Oct 07.
Article
em En
| MEDLINE
| ID: mdl-37803471
ABSTRACT
BACKGROUND:
Pembrolizumab as immunotherapy is increasingly used in adjuvant, neoadjuvant, and standalone therapy and has been described as safe. We share an experience of lung erosion post-thoracic surgery with the use of adjuvant pembrolizumab. CASE PRESENTATION A 65-year-old Chinese gentleman with metastatic renal cell carcinoma underwent lung metastasis resection and presented with delayed onset pneumothorax while on adjuvant pembrolizumab. Failure of conservative management warranted repeat surgical intervention, and intraoperative findings showed erosion of staple lines possibly caused by poor healing associated with pembrolizumab.CONCLUSION:
Adjuvant pembrolizumab may impair wound healing, including stapler line healing. Presentation of delayed pneumothorax in a post-surgical patient undergoing immunotherapy should warrant early surgical intervention.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumotórax
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Carcinoma de Células Renais
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Neoplasias Renais
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Neoplasias Pulmonares
Limite:
Aged
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Humans
Idioma:
En
Revista:
J Med Case Rep
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Singapura