Structural Analysis of Janus Tyrosine Kinase Variants in Hematological Malignancies: Implications for Drug Development and Opportunities for Novel Therapeutic Strategies.

Rodriguez Moncivais, Omar J; Chavez, Stephanie A; Estrada Jimenez, Victor H; Sun, Shengjie; Li, Lin; Kirken, Robert A; Rodriguez, Georgialina

Rodriguez Moncivais, Omar J; Chavez, Stephanie A; Estrada Jimenez, Victor H; Sun, Shengjie; Li, Lin; Kirken, Robert A; Rodriguez, Georgialina.

Afiliação

Rodriguez Moncivais OJ; Department of Biological Sciences, The University of Texas at El Paso, 500 W. University Ave., El Paso, TX 79902, USA.
Chavez SA; Border Biomedical Research Center, The University of Texas at El Paso, 500 W. University Ave., El Paso, TX 79902, USA.
Estrada Jimenez VH; Department of Biological Sciences, The University of Texas at El Paso, 500 W. University Ave., El Paso, TX 79902, USA.
Sun S; Border Biomedical Research Center, The University of Texas at El Paso, 500 W. University Ave., El Paso, TX 79902, USA.
Li L; Department of Biological Sciences, The University of Texas at El Paso, 500 W. University Ave., El Paso, TX 79902, USA.
Kirken RA; Border Biomedical Research Center, The University of Texas at El Paso, 500 W. University Ave., El Paso, TX 79902, USA.
Rodriguez G; Department of Physics, The University of Texas at El Paso, 500 W. University Ave., El Paso, TX 79902, USA.

Int J Mol Sci ; 24(19)2023 Sep 26.

Article em En | MEDLINE | ID: mdl-37834019

Assuntos

Neoplasias Hematológicas; Janus Quinases; Animais; Humanos; Camundongos; Janus Quinases/genética; Tirosina/genética; Janus Quinase 1/genética; Neoplasias Hematológicas/tratamento farmacológico; Neoplasias Hematológicas/genética; Mutação; Desenvolvimento de Medicamentos; Janus Quinase 2/genética; Receptores de Interferon/genética

Palavras-chave

Janus tyrosine kinase; computational modeling; gain-of-function mutations; hematological malignancies; homology modeling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Hematológicas / Janus Quinases Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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