CYFRA 21-1, CA 125 and CEA provide additional prognostic value in NSCLC patients with stable disease at first CT scan.
Tumour Biol
; 46(s1): S163-S175, 2024.
Article
em En
| MEDLINE
| ID: mdl-37840516
ABSTRACT
BACKGROUND:
Serum tumor markers (STM) may complement imaging and provide additional clinical information for patients with non-small cell lung cancer (NSCLC).OBJECTIVE:
To determine whether STMs can predict outcomes in patients with stable disease (SD) after initial treatment.METHODS:
This single-center, prospective, observational trial enrolled 395 patients with stage III/IV treatment-naïve NSCLC; of which 263 patients were included in this analysis. Computed Tomography (CT) scans were performed and STMs measured before and after initial treatment (two cycles of chemotherapy and/or an immune checkpoint inhibitor or tyrosine kinase inhibitor); analyses were based on CT and STM measurements obtained at first CT performed after cycle 2 only PFS and OS were analyzed by Kaplan-Meier curves and Cox-proportional hazard models.RESULTS:
When patients with SD (nâ=â100) were split into high- and low-risk groups based on CYFRA 21-1, CEA and CA 125 measurements using an optimized cut-off, a 4-fold increase risk of progression or death was estimated for high- vs low-risk SD patients (PFS, HR 4.17; OS, 3.99; both pâ<â0.0001). Outcomes were similar between patients with high-risk SD or progressive disease (nâ=â35) (OS, HR 1.17) and between patients with low-risk SD or partial response (nâ=â128) (PFS, HR 0.98; OS, 1.14).CONCLUSIONS:
STMs can provide further guidance in patients with indeterminate CT responses by separating them into high- and low-risk groups for future PFS and OS events.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Pulmonar de Células não Pequenas
/
Queratina-19
/
Neoplasias Pulmonares
/
Antígenos de Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Tumour Biol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Alemanha