Systemic meta-analysis: apigenin's effects on lung inflammation and oxidative stress.
J Asthma
; 61(4): 271-281, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-37851868
ABSTRACT
OBJECTIVE:
This study aimed to investigate the potential anti-inflammatory and antioxidant effects of apigenin in rats with acute lung injury (ALI). We also examined changes in levels of inflammatory and antioxidant factors after apigenin treatment in a rat model of ALI.Methods:
We searched several databases, including PubMed, Scopus, EMBASE, Web of Science, ProQuest, and GoogleScholar, to retrieve relevant articles for our systematic review and meta-analysis.Five studies with 226 rat models of ALI were included in this study. We investigated inflammatory factors and oxidative stress with the corresponding 95% confidence interval in three groups 1. Group1 (control vs. ALI), 2. Group2 (ALI vs. apigenin10), and 3. Group3 (ALI vs. apigenin20).RESULTS:
Estimating the correlation and 95% confidence intervals for the inflammatory agents and oxidative stress in the intervention group (ALI), compared with that in the control group, respectively (correlation 0.194; 95% confidence intervals, 0.101-0.282, p value = .001, z-value= 4.08) and (correlation 0.099; 95% confidence intervals, 0.016-0.182, p value = .020, z value= 2.325). Estimating the correlation and 95% confidence intervals for the inflammatory agents and oxidative stress in the intervention group (apigenin 10 mg/kg), compared with that in the control group (ALI), respectively (correlation 0.476; 95% confidence intervals, 0.391-0.553, p value = .001, z-value= 9.678) and (correlation 0.415; 95% confidence intervals, 0.313-0.508, p value= .001, z-value= 7.349).CONCLUSION:
Apigenin may have potential anti-inflammatory and antioxidant effects in rat models of ALI. However, the efficacy of apigenin as a therapeutic strategy requires further investigation through prospective controlled randomized trials.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumonia
/
Asma
/
Lesão Pulmonar Aguda
Tipo de estudo:
Systematic_reviews
Limite:
Animals
Idioma:
En
Revista:
J Asthma
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China