Disruption of hypoxia-inducible factor-2&#945; in neutrophils decreases colitis-associated colon cancer.

Singhal, Rashi; Kotla, Nikhil Kumar; Solanki, Sumeet; Huang, Wesley; Bell, Hannah N; El-Derany, Marwa O; Castillo, Cristina; Shah, Yatrik M

Disruption of hypoxia-inducible factor-2α in neutrophils decreases colitis-associated colon cancer.

Singhal, Rashi; Kotla, Nikhil Kumar; Solanki, Sumeet; Huang, Wesley; Bell, Hannah N; El-Derany, Marwa O; Castillo, Cristina; Shah, Yatrik M.

Afiliação

Singhal R; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Kotla NK; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Solanki S; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Huang W; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Bell HN; Cellular and Molecular Biology and Medical Scientist Training Program, University of Michigan, Ann Arbor, Michigan, United States.
El-Derany MO; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Castillo C; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Shah YM; Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Am J Physiol Gastrointest Liver Physiol ; 326(1): G53-G66, 2024 01 01.

Article em En | MEDLINE | ID: mdl-37933447

Assuntos

Neoplasias Associadas a Colite; Neoplasias do Colo; Animais; Camundongos; Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética; Peso Corporal; Carcinogênese/patologia; Transformação Celular Neoplásica/patologia; Neoplasias Associadas a Colite/genética; Neoplasias do Colo/genética; Neoplasias do Colo/patologia; Citocinas; Hipóxia; Subunidade alfa do Fator 1 Induzível por Hipóxia/genética; Inflamação; Neutrófilos; Microambiente Tumoral

Palavras-chave

HIF-2α; colitis; colorectal cancer; inflammation; neutrophil

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / Neoplasias Associadas a Colite Limite: Animals Idioma: En Revista: Am J Physiol Gastrointest Liver Physiol Assunto da revista: FISIOLOGIA / GASTROENTEROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

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