Enhanced spermatogonial stem cell killing and reduced translocation yield from X-irradiated 101/H mice.
Mutat Res
; 176(1): 69-79, 1987 Jan.
Article
em En
| MEDLINE
| ID: mdl-3796660
ABSTRACT
The spermatogonial stem cells of 101/H mice have been found to be more sensitive to killing by acute X-ray doses than those of the "standard" C3H/HeH X 101/H F1 hybrid. Duration of the sterile period was longer throughout the 0.5-8.0-Gy dose range tested and "recovered" testis weights, taken after recovery of fertility, were more severely reduced. The shapes of the sterile period dose-response curves were similar, but with the 101/H mice the plateau occurred at 3-5 Gy, rather than at 6 Gy. An equivalent observation was made with the testis weight data. The translocation dose-response curve was bell-shaped, as previously found with the hybrid, but yields were lower at all but the lowest doses. Notably, peak yields occurred at 3-5 Gy, rather than at 6 Gy. The altered stem cell killing and genetic responses may be explained either by a higher proportion of radiosensitive cells in the heterogeneous stem cell population or by a higher ratio of cell killing to recoverable chromosome damage which might imply a reduced repair capacity. The latter finds some support in other data. The pattern of genetic response obtained when an X-ray dose was given in two fractions at various intervals was similar in 101/H and the hybrid mice, suggesting that their kinetics of stem cell repopulation following depletion differ little.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espermatogônias
/
Espermatozoides
/
Translocação Genética
Limite:
Animals
Idioma:
En
Revista:
Mutat Res
Ano de publicação:
1987
Tipo de documento:
Article