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Two novel tumours with NTRK2 fusion in the methylation class of extraventricular neurocytomas, including one intraventricular.
Uro-Coste, Emmanuelle; Tauziede-Espariat, Arnault; Dubucs, Charlotte; Chiforeanu, Dan Christian; Siegfried, Aurore; Nicaise, Yvan; Bauchet, Luc; Riffaud, Laurent; Bielle, Franck; Vasiljevic, Alexandre; Appay, Romain; Evrard, Solène; Varlet, Pascale; Rigau, Valérie.
Afiliação
  • Uro-Coste E; Department of Pathology, Toulouse University Hospital, Toulouse, France.
  • Tauziede-Espariat A; INSERM U1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
  • Dubucs C; GHU Psychiatrie et Neurosciences, Site Sainte-Anne, Service de Neuropathologie, Paris, France.
  • Chiforeanu DC; Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR_S1266, INSERM, Equipe IMA-BRAIN (Imaging Biomarkers for Brain Development and Disorders), University of Paris, Paris, France.
  • Siegfried A; Department of Pathology, Toulouse University Hospital, Toulouse, France.
  • Nicaise Y; Department of Pathology, Rennes University Hospital, Rennes, France.
  • Bauchet L; Department of Pathology, Toulouse University Hospital, Toulouse, France.
  • Riffaud L; INSERM U1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
  • Bielle F; INSERM U1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
  • Vasiljevic A; Department of Neurosurgery, Montpellier University Hospital, Montpellier, France.
  • Appay R; Institute for Neuroscience of Montpellier (IGF), INSERM U1051, Montpellier University Hospital, Montpellier, France.
  • Evrard S; Department of Neurosurgery, University Hospital, Rennes, France.
  • Varlet P; Department of Neuropathology, AP-HP, Hôpitaux Universitaires Pitié-Salpêtrière Charles Foix, Paris, France.
  • Rigau V; Sorbonne University, UPMC, University of Paris, Paris, France.
Brain Pathol ; 34(3): e13223, 2024 May.
Article em En | MEDLINE | ID: mdl-37994695
ABSTRACT
We report here about two novel tumours classified as extraventricular neurocytomas (EVN) using DNA-methylation profiling, associated with NTRK2 fusions instead of the usual FGFR1 alterations so far attributed to this tumoural entity. We present the second detailed case of an intraventricular presentation in the MC EVN. Our findings broaden the spectrum of MC EVN and have implications in terms of diagnosis, therapy and terminology.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Neurocitoma Limite: Humans Idioma: En Revista: Brain Pathol Assunto da revista: CEREBRO / PATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: França
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Neurocitoma Limite: Humans Idioma: En Revista: Brain Pathol Assunto da revista: CEREBRO / PATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: França