Polygenic risk scores associate with blood pressure traits across the lifespan.
Eur J Prev Cardiol
; 31(6): 644-654, 2024 Apr 18.
Article
em En
| MEDLINE
| ID: mdl-38007706
A high genetic risk of elevated blood pressure (BP) is associated with increased BP from early childhood and throughout the lifespan. Inherited predispositions also affect the risk of cardiovascular morbidity and mortality, yet this appears to be modified by the absence or presence of hypertension, indicating that genetic hypertension risk is not deterministic, and that controlling BP can and should be done across the polygenic risk distribution. Given that differences in BP emerge early in life as a function of genetic risk, polygenic risk scores have the potential to reduce the duration of exposure to high BP by identifying high-risk individuals from birth, and thereby attenuate lifelong disease risk.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estratificação de Risco Genético
/
Hipertensão
Limite:
Adult
/
Child
/
Humans
Idioma:
En
Revista:
Eur J Prev Cardiol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Noruega