Combination of eriocalyxin B and homoharringtonine exerts synergistic anti-tumor effects against t(8;21) AML.

Lei, Yi-Chen; Chen, Xin-Jie; Dai, Yu-Ting; Dai, Bing; Wang, Ji-Yue; Li, Miao-Hui; Liu, Ping; Liu, Han; Wang, Kan-Kan; Jiang, Lu; Chen, Bing

Lei, Yi-Chen; Chen, Xin-Jie; Dai, Yu-Ting; Dai, Bing; Wang, Ji-Yue; Li, Miao-Hui; Liu, Ping; Liu, Han; Wang, Kan-Kan; Jiang, Lu; Chen, Bing.

Afiliação

Lei YC; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Chen XJ; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Dai YT; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Dai B; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Wang JY; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Li MH; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Liu P; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Liu H; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Wang KK; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Jiang L; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. jianglu125@126.com.
Chen B; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. chenbing_rjh@163.com.

Acta Pharmacol Sin ; 45(3): 633-645, 2024 Mar.

Article em En | MEDLINE | ID: mdl-38017299

Assuntos

Subunidade alfa 2 de Fator de Ligação ao Core; Diterpenos; Leucemia Mieloide Aguda; Humanos; Animais; Camundongos; Mepesuccinato de Omacetaxina/farmacologia; Mepesuccinato de Omacetaxina/uso terapêutico; Subunidade alfa 2 de Fator de Ligação ao Core/genética; Subunidade alfa 2 de Fator de Ligação ao Core/metabolismo; Subunidade alfa 2 de Fator de Ligação ao Core/uso terapêutico; Translocação Genética; Proteína 1 Parceira de Translocação de RUNX1/genética; Leucemia Mieloide Aguda/tratamento farmacológico; Leucemia Mieloide Aguda/genética

Palavras-chave

KIT; RUNX1-RUNX1T1; eriocalyxin B; homoharringtonine; synergistic effect; t(8;21) AML

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Diterpenos / Subunidade alfa 2 de Fator de Ligação ao Core Limite: Animals / Humans Idioma: En Revista: Acta Pharmacol Sin Assunto da revista: FARMACOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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