Bacterial colonisation of the airway in neonates and risk of asthma and allergy until age 18â
years.
Eur Respir J
; 63(1)2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38097209
ABSTRACT
BACKGROUND:
We previously showed an association between neonatal bacterial airway colonisation and increased risk of persistent wheeze/asthma until age 5â years. Here, we study the association with persistent wheeze/asthma and allergy-related traits until age 18â years.METHODS:
We investigated the association between airway colonisation with Streptococcus pneumoniae, Moraxella catarrhalis and/or Haemophilus influenzae in 1-month-old neonates from the COPSAC2000 mother-child cohort and the development of persistent wheeze/asthma and allergy-related traits longitudinally until age 18â years using generalised estimating equations. Replication was sought in the similarly designed COPSAC2010 cohort of 700 children.RESULTS:
Neonatal airway colonisation was present in 66 (21%) out of 319 children and was associated with a 4-fold increased risk of persistent wheeze/asthma (adjusted OR 4.01 (95% CI 1.76-9.12); p<0.001) until age 7â years, but not from age 7 to 18â years. Replication in the COPSAC2010 cohort showed similar results using 16S data. Colonisation was associated with an increased number of exacerbations (adjusted incidence rate ratio 3.20 (95% CI 1.38-7.44); p<0.01) until age 7â years, but not from age 7 to 18â years. Colonisation was associated with increased levels of blood eosinophils (adjusted geometric mean ratio 1.24 (95% CI 1.06-1.44); p<0.01) and tumour necrosis factor (TNF)-α (adjusted geometric mean ratio 1.09 (95% CI 1.02-1.16); p=0.01) until age 12â years. There were no associations with lung function, bronchial reactivity, fractional exhaled nitric oxide, allergic sensitisation, total IgE or atopic dermatitis up to age 18â years.CONCLUSIONS:
Neonatal airway colonisation was associated with early-onset persistent wheeze/asthma, exacerbations, elevated blood eosinophils and elevated TNF-α in blood, most prominent in early childhood, thereafter diminishing and no longer evident by age 18â years.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Dermatite Atópica
/
Hipersensibilidade
Limite:
Adolescent
/
Child
/
Child, preschool
/
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
Eur Respir J
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Dinamarca