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APOBEC3 as a driver of genetic intratumor heterogeneity.
Venkatesan, Subramanian; Angelova, Mihaela; Bartkova, Jirina; Bakhoum, Samuel F; Bartek, Jiri; Kanu, Nnennaya; Swanton, Charles.
Afiliação
  • Venkatesan S; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
  • Angelova M; Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, UK.
  • Bartkova J; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
  • Bakhoum SF; Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Bartek J; Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden.
  • Kanu N; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Swanton C; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Mol Cell Oncol ; 10(1): 2014734, 2023.
Article em En | MEDLINE | ID: mdl-38116246
ABSTRACT
Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mol Cell Oncol Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mol Cell Oncol Ano de publicação: 2023 Tipo de documento: Article