[Progress of researches on developmental processes and reproduction mode of Pneumocystis].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
; 35(5): 522-528, 2023 Oct 24.
Article
em Zh
| MEDLINE
| ID: mdl-38148544
ABSTRACT
Pneumocystis, an important opportunistic fungal pathogen that parasitizes in multiple mammalian lungs, may cause life-threatening Pneumocystis pneumonia (PCP) and even death among immunocompromised individuals. With the rapid development of high-throughput sequencing and multi-omics technologies, systematic comparative analyses of genome, transcriptome, and whole-genome sequencing results demonstrate that Pneumocystis is a type of obligate biotrophic fungi, and requires obtaining nutrition from hosts. In addition, sexual reproduction is an essential process for Pneumocystis survival, production and transmission, and asexual reproduction facilitates Pneumocystis survival, which provides new insights into understanding of the whole developmental process of Pneumocystis in the host lung and inter-host transmission of Pneumocystis. This review summarizes the advances in the reproduction mode of Pneumocystis and underlying mechanisms, which provides insights into prevention and treatment of PCP, notably for the prophylaxis against nosocomial transmission of PCP.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumocystis
/
Pneumonia por Pneumocystis
Limite:
Humans
Idioma:
Zh
Revista:
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China