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In situ setup for screening of drug permeation by NMR spectroscopy.
Mildner, Malte; Hanio, Simon; Endres, Sebastian; Scheller, Lena; Engel, Bettina; Castañar, Laura; Meinel, Lorenz; Pöppler, Ann-Christin.
Afiliação
  • Mildner M; Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany. ann-christin.poeppler@uni-wuerzburg.de.
  • Hanio S; Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany.
  • Endres S; Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany. ann-christin.poeppler@uni-wuerzburg.de.
  • Scheller L; Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany.
  • Engel B; Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany.
  • Castañar L; Department of Organic Chemistry, Faculty of Chemical Science, Complutense University of Madrid, Madrid, Spain.
  • Meinel L; Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany.
  • Pöppler AC; Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany. ann-christin.poeppler@uni-wuerzburg.de.
Anal Methods ; 16(10): 1468-1472, 2024 03 07.
Article em En | MEDLINE | ID: mdl-38226670
ABSTRACT
There are various commercially available setups for studying drug permeation, which differ in cost and manual labor. We explore an artificial membrane in an NMR tube to assess drug permeation with automated measurements. NMR-based concentrations were validated with HPLC and compared to a conventional setup. Setup-specific challenges and workarounds as well as future setup-designs for this and other applications are discussed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Membranas Artificiais Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Revista: Anal Methods Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Membranas Artificiais Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Revista: Anal Methods Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Alemanha