Immune Biology and Persistence of Helicobacter pylori in Gastric Diseases.
Curr Top Microbiol Immunol
; 444: 83-115, 2023.
Article
em En
| MEDLINE
| ID: mdl-38231216
ABSTRACT
Helicobacter pylori is a prevalent pathogen, which affects more than 40% of the global population. It colonizes the human stomach and persists in its host for several decades or even a lifetime, if left untreated. The persistent infection has been linked to various gastric diseases, including gastritis, peptic ulcers, and an increased risk for gastric cancer. H. pylori infection triggers a strong immune response directed against the bacterium associated with the infiltration of innate phagocytotic immune cells and the induction of a Th1/Th17 response. Even though certain immune cells seem to be capable of controlling the infection, the host is unable to eliminate the bacteria as H. pylori has developed remarkable immune evasion strategies. The bacterium avoids its killing through innate recognition mechanisms and manipulates gastric epithelial cells and immune cells to support its persistence. This chapter focuses on the innate and adaptive immune response induced by H. pylori infection, and immune evasion strategies employed by the bacterium to enable persistent infection.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Helicobacter pylori
Limite:
Humans
Idioma:
En
Revista:
Curr Top Microbiol Immunol
/
Curr. top. microbiol. immunol
/
Current topics in microbiology and immunology
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Alemanha