Interplay between polygenic risk for mood disorders and stressful life events in bipolar disorder.
J Affect Disord
; 350: 565-572, 2024 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-38246285
ABSTRACT
BACKGROUND:
Although genetic and environmental factors are involved in the aetiology of bipolar disorder [BD], studies focused on their interplay are lacking. The current investigation examines interactions and correlations between polygenic risk scores [PRS] for BD and major depressive disorder [MDD] with stressful life events [SLEs] in liability for BD.METHODS:
This study used data from 1715 participants (862 bipolar cases and 853 controls) taken from UK and Canadian samples. The List of Threatening Experiences Questionnaire recorded SLEs that occurred 6 months before interview for controls and 6 months prior to the first (Canadian sample) and worst (UK sample) depressive and manic episodes for bipolar cases. PRS-BD and PRS-MDD were calculated from the Psychiatric Genomics Consortium.RESULTS:
For the worst depressive episode, the PRS-MDD was significantly correlated with total number of SLEs (ß = 0.13, 95 % CI0.04-0.22, p = 0.003) and dependent SLEs (ß = 0.09, 95 % CI0.02-0.16, p = 0.007). After correction for multiple testing nominally significant correlations were detected for PRS-BD with total number of SLEs (ß = 0.11, 95 % CI0.02-0.20, p = 0.015) and dependent SLEs (ß = 0.08, 95 % CI0.01-0.15, p = 0.019). Among bipolar cases, these associations were slightly stronger but were only of nominal significance for total number of SLEs (PRS-MDD ß = 0.19, 95 % CI0.04-0.35, p = 0.015; PRS-BD ß = 0.16, 95 % CI0.01-0.32, p = 0.042) and dependent SLEs (PRS-MDD ß = 0.14, 95 % CI0.03-0.26, p = 0.015; PRS-BD ß = 0.12, 95 % CI0.004-0.24, p = 0.043). No other significant gene-environment correlations or interactions were found.LIMITATIONS:
Use of a larger sample size would be beneficial.CONCLUSIONS:
The relationship between SLEs and genetic risk for mood disorders may be best explained through correlations rather than interactions.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtorno Bipolar
/
Transtorno Depressivo Maior
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Affect Disord
Ano de publicação:
2024
Tipo de documento:
Article